claforan cefotaxime sodium injection

Description: Cefotaxime binds to 1 or more of the penicillin-binding proteins (PBPs) which inhibit the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Pharmacokinetics: Absorption: Rapidly absorbed (IM).Time to peak plasma concentration: 30 min (IM), 4 hr (IV).

CLAFORAN (cefotaxime for injection) is a semi-synthetic, 2-aminothiazolyl cephalosporin antibiotic for parenteral use. In vitro studies indicate that the antibacterial action of CLAFORAN results from inhibition of cell wall synthesis. It is stable against the action of most β

How to use Claforan Vial This medication is given by injection into a muscle or vein as directed by your doctor. If given by injection into a vein, inject the drug slowly over at least 3 minutes to

Nov 16,  · CLAFORAN contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of CLAFORAN range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5. The CAS Registry Number is 64485-93-4.

How to use cefotaxime injection This medication is given by injection into a muscle or vein as directed by your doctor. If given by injection into a vein, inject the drug slowly over at least 3 minutes to avoid possible serious side effects (such as irregular heartbeat). The dosage is based on your medical condition and response to treatment.

Cefotaxime is an antibiotic used to treat a number of bacterial infections. Specifically it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. It is given either by injection into a vein or muscle.

Cefotaxime, better known as Claforan®, is an injectable antibiotic sometimes used for dogs and cats. It is further categorized as a third generation cephalosporin given by intramuscular or intravenous injection to treat susceptible infections. It is bactericidal and works by inhibiting mucopeptide synthesis in the bacterial cell wall.

Cefotaxime is also used in the treatment of serious bacteremia, pneumonia, intra-abdominal infections, bone and joint infections, urinary tract infections, and skin and skin structure infections. Cefotaxime is FDA-approved for use in pediatric patients as young as neonates.

Mar 23,  · Claforan contains approximately 50.5 mg (2.2 mEq) of sodium per gram of cefotaxime activity. Solutions of Claforan range from very pale yellow to light amber depending on the concentration and the diluent used. The pH of the injectable solutions usually ranges from 5.0 to 7.5. The CAS Registry Number is 64485-93-4.

Leukopenia, neutropenia and, more rarely, bone marrow failure, pancytopenia or agranulocytosis may develop during treatment with cefotaxime, particularly if given over long periods. For treatment courses lasting longer than 7-10 days, the blood white cell count should be monitored and treatment stopped in the event of neutropenia.

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For patients on sodium restriction, note that cefotaxime contains 2.2 mEq of sodium per gram of drug. • For I.M. injection, add 2 ml, 3 ml, or 5 ml of sterile or bacteriostatic water for injection to each 500-mg, 1-g, or 2-g vial. Shake well to dissolve drug completely. Check solution for particles and discoloration.

cefoTAXime Sodium for Injection BP (cefotaxime sodium) may be indicated for the treatment of infections caused by susceptible strains of the designated micro-organisms* in the diseases listed below: • Lower Respiratory Tract Infections • Urinary Tract Infections

May 25,  · Intramuscular Add 3 mL sterile water for injection or bacteriostatic water for injection to vial containing 1 g drug, providing a solution of approximately 300 mg cefotaxime/mL. Administer IM injection deeply into large muscle mass (e.g., upper outer quadrant of gluteus maximus). Aspirate to avoid inadvertent injection into blood vessel.

Mar 16,  · Claforan injection, Baxter, 2 gram/50 mL, frozen premixed bag, 24 count, NDC 00039-0039-05 - discontinued. Cefotaxime Sodium powder for solution for injection, Hikma, 1 gram, vial, 25 count, NDC 00143-9931-25. Cefotaxime Sodium powder for solution for injection, Hikma, 10 gram, vial, 1 count, NDC 00143-9935-01.

Sep 21,  · Cefotaxime Sodium; Routes. Dosage Forms. Strengths. Brand Names. Manufacturer. Parenteral. For injection. 500 mg (of cefotaxime)* Cefotaxime Sodium for Injection. Claforan. Sanofi-Aventis. 1 g (of cefotaxime)* Cefotaxime Sodium for Injection. Claforan. Sanofi-Aventis. 2 g (of cefotaxime)* Cefotaxime Sodium for Injection. Claforan. Sanofi-Aventis

Sterile CLAFORAN (cefotaxime sodium) is a semisynthetic, broad spectrum cephalosporin antibiotic for parenteral administration. It is the sodium salt of 7-[2-(2-amino-4-thiazolyl) glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1-azabicyclo [4.2.0] oct-2-ene-2- carboxylate 72

Jan 31,  · Compatible with sodium chloride 0.9%, glucose 5% and glucose 10% Do NOT mix with other drugs, IV solutions, strongly alkaline solutions, blood or blood products. Flush line with sodium chloride 0.9% before and after infusion of cefotaxime. Separate administration from aminoglycoside antibiotics by one hour eg. gentamicin, amikacin.³

Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy. May need to adjust dose in renal impairment. Cefotaxime may potentiate the nephrotoxic

Jun 04,  · Cefotaxime : Therapeutic uses, Dosage & Side Effects. Cefotaxime is the prototype of the third generation cephalosporins. It is deacetylated in the body; the metabolite exerts weaker but synergistic action with the parent drug. Dose : 1-2 g i.m./i.v. 8

Jan 22,  · Expand Section. Cefotaxime injection is used to treat certain infections caused by bacteria including pneumonia and other lower respiratory tract (lung) infections; gonorrhea (a sexually transmitted disease); meningitis (infection of the membranes that surround the brain and spinal cord) and other brain and spinal cord infections; and abdominal (stomach area), reproductive organs, skin, blood,

Cefotaxime may decrease the excretion rate of Sodium aurothiomalate which could result in a higher serum level. Sodium citrate The therapeutic efficacy of Sodium citrate can be decreased when used in combination with Cefotaxime.

Injection (cefotaxime injection, USP) To reduce the development of drug-resistant bacteria and maintain the effectiveness of CLAFORAN (cefotaxime sodium) and other antibacterial drugs, CLAFORAN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Cefotaxime sodium Cas no. : 64485-93-4 Molecular Formula : C16H16N5NaO7S2 EINECS No. : 264-915-9 Molecular Weight : 477.44 Purity : 99.5 % Appearance : This product is white, almost white or yellowish white crystalline powder; odorless or slight special smell.

CEFOTAXIME (sef oh TAKS eem) is a cephalosporin antibiotic. It treats some infections caused by bacteria. It will not work for colds, the flu, or other viruses.

Jul 18,  · Common side effects of cefotaxime include: irritation at the site of injection; diarrhea; rash; itching; diarrhea; nausea; vomiting; fever; This is not a complete list of cefotaxime side effects. Ask your doctor or pharmacist for more information. Serious side effects have been reported with cefotaxime. See the “Drug Precautions” section.